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・ Tetrahydrobiopterin
・ Tetrahydrobiopterin deficiency
・ Tetrahydrocannabinol
・ Tetrahydrocannabinol-C4
・ Tetrahydrocannabinolic acid
・ Tetrahydrocannabinolic acid synthase
・ Tetrahydrocannabivarin
・ Tetrahydrocolumbamine 2-O-methyltransferase
・ Tetrahydrocoptisine
・ Tetrahydrocorticosterone
・ Tetrahydrocortisol
・ Tetrahydrocortisone
・ Tetrahydrodeoxycorticosterone
・ Tetrahydrodipicolinate N-acetyltransferase
・ Tetrahydrofolate riboswitch
Tetrahydrofolate synthase
・ Tetrahydrofolic acid
・ Tetrahydrofuran
・ Tetrahydrofuran (data page)
・ Tetrahydrogestrinone
・ Tetrahydroharman
・ Tetrahydroharmine
・ Tetrahydroharmol
・ Tetrahydroisoquinoline
・ Tetrahydromethanopterin
・ Tetrahydromethanopterin S-methyltransferase
・ Tetrahydropalmatine
・ Tetrahydroprogesterone
・ Tetrahydropyran
・ Tetrahydrosarcinapterin synthase


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Tetrahydrofolate synthase : ウィキペディア英語版
Tetrahydrofolate synthase

In enzymology, a tetrahydrofolate synthase () is an enzyme that catalyzes the chemical reaction
:ATP + tetrahydropteroyl-()n + L-glutamate \rightleftharpoons ADP + phosphate + tetrahydropteroyl-()n+1
The 3 substrates of this enzyme are ATP, )n" TITLE="tetrahydropteroyl-()n">tetrahydropteroyl-()n, and L-glutamate, whereas its 3 products are ADP, phosphate, and )n+1" TITLE="tetrahydropteroyl-()n+1">tetrahydropteroyl-()n+1.
This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is tetrahydropteroyl-gamma-polyglutamate:L-glutamate gamma-ligase (ADP-forming). Other names in common use include folylpolyglutamate synthase, folate polyglutamate synthetase, formyltetrahydropteroyldiglutamate synthetase, N10-formyltetrahydropteroyldiglutamate synthetase, folylpoly-gamma-glutamate synthase, folylpolyglutamyl synthetase, folylpoly(gamma-glutamate) synthase, folylpolyglutamate synthetase, folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase, FPGS, tetrahydrofolylpolyglutamate synthase, tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming), tetrahydropteroyl-()n:L-glutamate gamma-ligase, and (ADP-forming). This enzyme participates in folate biosynthesis.
==Structural studies==

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes , , , , , , and .

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