|
In enzymology, a tetrahydrofolate synthase () is an enzyme that catalyzes the chemical reaction :ATP + tetrahydropteroyl-()n + L-glutamate ADP + phosphate + tetrahydropteroyl-()n+1 The 3 substrates of this enzyme are ATP, )n" TITLE="tetrahydropteroyl-()n">tetrahydropteroyl-()n, and L-glutamate, whereas its 3 products are ADP, phosphate, and )n+1" TITLE="tetrahydropteroyl-()n+1">tetrahydropteroyl-()n+1. This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is tetrahydropteroyl-gamma-polyglutamate:L-glutamate gamma-ligase (ADP-forming). Other names in common use include folylpolyglutamate synthase, folate polyglutamate synthetase, formyltetrahydropteroyldiglutamate synthetase, N10-formyltetrahydropteroyldiglutamate synthetase, folylpoly-gamma-glutamate synthase, folylpolyglutamyl synthetase, folylpoly(gamma-glutamate) synthase, folylpolyglutamate synthetase, folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase, FPGS, tetrahydrofolylpolyglutamate synthase, tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming), tetrahydropteroyl-()n:L-glutamate gamma-ligase, and (ADP-forming). This enzyme participates in folate biosynthesis. ==Structural studies== As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes , , , , , , and . 抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「Tetrahydrofolate synthase」の詳細全文を読む スポンサード リンク
|